Plasma concentrations and sedation scores after nebulized and intranasal midazolam in healthy volunteers
نویسندگان
چکیده
منابع مشابه
Plasma concentrations and sedation scores after nebulized and intranasal midazolam in healthy volunteers.
BACKGROUND An efficacious, reliable, and non-invasive route of administration for midazolam, a drug used for sedation and pre-anaesthetic medication, would have obvious advantages. This study compares two potential methods of administering midazolam by the nasal and nebulized routes. METHODS Midazolam (0.2 mg kg(-1)) was given by both nebulizer and nasally by liquid instillation to 10 healthy...
متن کاملPharmacokinetics and pharmacodynamics of a new intranasal midazolam formulation in healthy volunteers.
We evaluated the pharmacokinetics and pharmacodynamics of single 5-mg doses of midazolam after administration of a novel intranasal (IN) formula, IM, and IV midazolam in an open-label, randomized, 3-way cross-over study in 12 healthy volunteers. IN doses were delivered as 0.1-mL unit-dose sprays of a novel formulation into both naris. Blood samples were taken serially from 0 to 12 h after each ...
متن کاملAnesthesia and Sedation in Chough (Pyrrhocorax pyrrhocorax) Following Intranasal Administration of Diazepam, Midazolam, Xylazine with or without Ketamine: Clinical Evaluation
Objective- This study aimed to compare sedation efficacy in intranasal administration of xylazine, diazepam and midazolam with or without ketamine in Chough. Design- To determine the sedation efficacy, an experimental in vivo study was employed. Animals- Seven healthy Choughs were examined in the current study. Procedu...
متن کاملPharmacokinetic Modelling of Lamotrigine from Plasma Concentrations in Healthy Volunteers
The pharmacokinetics of the antiepileptic agent lamotrigine (CAS 84057-84-1) was investigated after single oral doses in 14 healthy volunteers. After the administration of single oral doses of 2x100 mg lamotrigine chewable/soluble tablets to healthy volunteers, blood samples were collected for the next 96 h. The pharmacokinetic modelling of lamotrigine showed that the drug exhibited two compart...
متن کاملIncrease in Plasma Concentrations of Geranylgeranoic Acid after Turmeric Tablet Intake by Healthy Volunteers
Geranylgeranoic acid (GGA) is one of the most potent cancer-preventive acyclic retinoids. GGA has been shown to induce cell death in human hepatoma-derived HuH-7 cells. We have recently reported the natural occurrence of GGA and its related compounds in several medicinal herbs such as turmeric, basil, rosehip, cinnamon and others [Shidoji and Ogawa, J. Lipid Res., 45: 1092-1103, 2004]. In the p...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 2008
ISSN: 0007-0912
DOI: 10.1093/bja/aen072